|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
CLCA1 expression was denoted as positive in 90 tumors (64.3%), with positive staining being limited to the tumor cells.
|
30419838 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer.
|
11445004 |
2001 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In addition, CLCA1 serum concentration and mRNA expression level in CRC tissues were inversely correlated with CRC metastasis and tumor stage.
|
28974231 |
2017 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
<b>Results:</b> In validation cohort, high expression of CLCA1 was significantly associated with higher pre-treatment tumor nodal stages (P=0.032), vascular invasion (P=0.028), and inferior tumor regression grade (P=0.042).
|
30123054 |
2018 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The source of the data was The Cancer Genome Atlas, and it was identified that high expression levels of CLCA1 and CLCA2 were associated with a favorable overall survival (OS) time in patients with colon cancer.
|
31404307 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In this review, the functional role of CLCA1, with a particular focus on cancer, is described.
|
30952704 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on cancer cell aggregation.
|
26004777 |
2015 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on cancer cell aggregation.
|
26004777 |
2015 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
In this review, the functional role of CLCA1, with a particular focus on cancer, is described.
|
30952704 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The source of the data was The Cancer Genome Atlas, and it was identified that high expression levels of CLCA1 and CLCA2 were associated with a favorable overall survival (OS) time in patients with colon cancer.
|
31404307 |
2019 |
|
Respiratory Syncytial Virus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
RNO inhibited RSV infection of WD-HBE, prevented the loss of ciliated cells and markers, reduced the increase of MUC5AC and CLCA1 and inhibited the increase of IL-13, IL-6, IL-8, TNFα and ICAM-1.
|
23936072 |
2013 |
|
Respiratory Syncytial Virus Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
To demonstrate a causative link, we depleted TLR3-/- mice of IL-13 during RSV infection and found that mucus and gob5 expression in the lungs was attenuated.
|
16424225 |
2006 |
|
Respiration Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The secreted airway mucus cell protein chloride channel regulator, calcium-activated 1, CLCA1, plays a role in inflammatory respiratory diseases via as yet unidentified pathways.
|
29610986 |
2018 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Viral infection (staining of F and G proteins, nucleoprotein RNA level), mRNA of ICAM-1, ciliated cell markers (digital high speed videomicroscopy, β-tubulin immunofluorescence, Foxj1 and Dnai2 mRNA), Goblet cells (PAS), mRNA of MUC5AC and CLCA1, mRNA and protein level of IL-13, IL-6, IL-8, TNFα, formation of H2O2 and the anti-oxidative armamentarium (mRNA of Nrf2, HO-1, GPx; total antioxidant capacity (TAC) were measured at day 10 or 15 post infection.
|
23936072 |
2013 |
|
Eosinophilic disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
CLCA1 mRNA and periostin protein, previously identified biomarkers of IL-13-mediated epithelial activation, were elevated in columnar epithelial cell-high sputum samples, but only when accompanied by eosinophilia.
|
31264263 |
2019 |
|
Hypertriglyceridemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of the two major SNPs from APOA5 [c.56C > G, c.-3A > G] and from APOC3 [c.102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26).
|
16125709 |
2006 |
|
Metaplasia
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction.
|
12568493 |
2002 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, CLCA1 serum concentration and mRNA expression level in CRC tissues were inversely correlated with CRC metastasis and tumor stage.
|
28974231 |
2017 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The data demonstrated the up-regulated TFs such as GATA-3, AP4, c-Myc and Pbx1 in the gastric mucosa of GC patients compared with the healthy volunteers, while other TFs, particularly CCAAT and CACC, showed the consistently decreasing trend along the gastric carcinogenesis.
|
26563475 |
2015 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Results:</b> In validation cohort, high expression of CLCA1 was significantly associated with higher pre-treatment tumor nodal stages (P=0.032), vascular invasion (P=0.028), and inferior tumor regression grade (P=0.042).
|
30123054 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into TH2-high and TH2-low endotypes.
|
24075231 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells.
|
16148052 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB).
|
16364194 |
2006 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because of its involvement in other airway diseases, such as asthma, we hypothesized that Ca²⁺-activated Cl⁻ channel 1 (CLCA1) was associated with overproduction of mucus in the airways of smokers and COPD patients.
|
22731784 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicated that gob-5 may play a critical role in murine asthma, and its human counterpart hCLCA1 is therefore a potential target for asthma therapy.
|
11296262 |
2001 |